NURS 6630 Discussion Psychiatric Mental Health
NURS 6630 Discussion Psychiatric Mental Health
NURS 6630 Discussion Psychiatric Mental Health
I really enjoyed reading your article, it was very informative and detailed. I will like to share additional insight I found interesting too.
According to Berg and Clarke (2018), Agonists have intrinsic efficacy (the ability to increase the activity of a receptor), and inverse agonists are said to have negative intrinsic efficacy (the ability to decrease the activity of a receptor). Just as agonist intrinsic efficacy for a receptor varies with the structure of the agonist (resulting in strong agonists and weaker [partial] agonists), inverse agonists also have different degrees of negative intrinsic efficacy, resulting in strong and weak (partial) inverse agonists.
Inverse agonists are ligands that selectively bind to the inactive state of the receptor (Kenakin, 2017). If any receptor happens to be in an active state spontaneously, then an inverse agonist will reverse the resultant constitutive activity. However, the main pharmacological effect of inverse agonists is receptor antagonism, that is, inverse agonists will block the effect of agonists and the effect on constitutive activity is only relevant if the system is spontaneously active (Kenakin, 2017). There is a property of inverse agonists that may be therapeutically relevant in nonconstitutively active systems (Kenakin, 2017).
References
Berg, K. A., & Clarke, W. P. (2018). Making sense of pharmacology: Inverse agonism and functional selectivity. The international journal of neuropsychopharmacology, 21(10), 962–977. https://doi.org/10.1093/ijnp/pyy071
Kenakin, T. P. (2017). Pharmacology in Drug Discovery and Development (Second Edition). ScienceDirect. Retrieved June 10, 2022, from https://doi.org/10.1016/B978-0-12-803752-2.00004-1
As a psychiatric mental health nurse practitioner, it is essential for you to have a strong background in foundational neuroscience. In order to diagnose and treat clients, you must not only understand the pathophysiology of psychiatric disorders, but also how medications for these disorders impact the central nervous system. These concepts of foundational neuroscience can be challenging to understand. Therefore, this Discussion is designed to encourage you to think through these concepts, develop a rationale for your thinking, and deepen your understanding by interacting with your colleagues.
Required Readings
Note: All Stahl resources can be accessed through the Library using this link. This link will take you to a log-in page for the Library. Once you log into the library, the Stahl website will appear.
Stahl, S. M. (2013). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press *Preface, pp. ix–x
Note: To access the following chapters, click on the Essential Psychopharmacology, 4th ed tab on the Stahl Online website and select the appropriate chapter. Be sure to read all sections on the left navigation bar for each chapter.
Chapter 1, “Chemical Neurotransmission”
Chapter 2, “Transporters, Receptors, and Enzymes as Targets of Psychopharmacologic Drug Action”
Chapter 3, “Ion Channels as Targets of Psychopharmacologic Drug Action”
Document: Midterm Exam Study Guide (PDF)
Document: Final Exam Study Guide (PDF)
NURS 6630 Discussion Psychiatric Mental Health
Required Media
Laureate Education (Producer). (2016i). Introduction to psychopharmacology [Video file]. Baltimore, MD: Author.
Note: The approximate length of this media piece is 3 minutes.
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Optional Resources
Laureate Education (Producer). (2009). Pathopharmacology: Disorders of the nervous system: Exploring the human brain [Video file]. Baltimore, MD: Author.
Note: The approximate length of this media piece is 15 minutes.
Dr. Myslinski reviews the structure and function of the human brain. Using human brains, he examines and illustrates the development of the brain and areas impacted by disorders associated with the brain.
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Laureate Education (Producer). (2012). Introduction to advanced pharmacology [Video file]. Baltimore, MD: Author.
Note: The approximate length of this media piece is 8 minutes.
In this media presentation, Dr. Terry Buttaro, associate professor of practice at Simmons School of Nursing and Health Sciences, discusses the importance of pharmacology for the advanced practice nurse.
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To prepare for this Discussion:
Review this week’s Learning Resources.
Reflect on concepts of foundational neuroscience.