DQ: Using the GCU Library (notably the GCU Library: Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
NUR 550 Topic 1 DQ 2
DQ Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
When looking through the GCU library for an interesting study containing translational research, I found this study called “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” (Harischandra et. Al, 2020). This study states that there are treatment options out there for those patients with Parkinsons, like deep brain stimulation and medications like levodopa, but these treatments are only touching the surface of the issue at hand (Harischandra et. al, 2020). They state that for future (better) treatment for these patients they need to look at the dopaminergic neurons as well as the dopamine transporter (Harischandra, et. Al, 2020). They attempted to preform studies on rats but found that the cells differed in a way that would not give them accurate results (Harishchandra, et. Al, 2020). They then went on to utilize embryonic stem cells and developing these into LUHMES cells which more closely resembled the pathways they were trying to achieve (Harischandra, et. Al, 2020). By doing their experiments on these cells they are in the T1 transition, pre patient and practice, in the lab studying the real effects on the neural pathways (Translational Research, n.d.). I’m not going to lie the study is lengthy and the process they utilized involved a ton of chemicals and days of watching these cells develop into what they needed, but at the end of 5 days their processes had drastically increased the reuptake of dopamine in the cells (Hasichandra, et. Al, 2020). Stem Cells are not always available for drug research so being able to develop these LUHMES cells to test on is great for the future of Parkinson’s research and for testing drugs (Harischandra et. Al, 2020).
DQ Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533
Translational Research – Defining the “T’s” | Translational Cancer Research Network. (n.d.). Www.Tcrn.Unsw.Edu. Retrieved June 18, 2021, from http://www.tcrn.unsw.edu.au/translational-research-definitions
RESPOND HERE (150 WORDS, 2 REFERENCES)
This is insightful, Sarah, the study, “Enhanced differentiation of human dopaminergic neural cell model for preclinical translational research in Parkinson’s disease.” Contains translational research expressed in different ways. The study highlighted indicates different
DQ Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
methods or options for managing or treating Parkinson’s (Harischandra et al., 2020). The article further elaborates that the approaches applied only touch on the surface of the issue that has been identified. From the research study highlighted, there is the application of T1 translational research. The approach that has been used has proved critical when it comes to the determination of the outcomes of the research process. From the study highlighted, it has been found that Parkinson’s is a disease or disorder that greatly impacts the functioning of the brain. The conditions often lead to stiffness, shaking, and difficulty with body balance, walking, as well as general coordination (Rubio et al., 2019). The study highlighted that the symptoms of Parkinson’s diseases normally start and progress gradually and worsen over time. As the disease progresses, there is always difficulty in talking and walking.
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References
Harischandra, D. S., Rokad, D., Ghaisas, S., Verma, S., Robertson, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2020). Enhanced differentiation of human dopaminergic neuronal cell model for preclinical translational research in Parkinson’s disease. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1866(4), 165533. https://doi-org.lopes.idm.oclc.org/10.1016/j.bbadis.2019.165533
Rubio, I., Osuchowski, M. F., Shankar-Hari, M., Skirecki, T., Winkler, M. S., Lachmann, G., … & Bermejo-Martín, J. F. (2019). Current gaps in sepsis immunology: new opportunities for translational research. The Lancet Infectious Diseases, 19(12), e422-e436. https://www.sciencedirect.com/science/article/abs/pii/S1473309919305675
Incidences of stroke in the U.S. have declined in the past few years for the first time in history. However, stroke incidence among older adults has always been higher than younger adults, especially older women (Portz et al., 2018). Older adults of 80 years and above make about 17% of all stroke patients and are at high risk of mortality and prolonged hospital stays (Portz et al., 2018). This journal is in phase T4 type of translational research, where the information obtained in the previous stages is disseminated and implemented. This translational research aimed to investigate the impact of physical fitness and exercises for older adults with chronic stroke. A large body of literature has examined the correlation between self-management intervention such as physical fitness and exercise and chronic stroke. For instance, Schmid et al. (2014) observed that patients with chronic stroke showed physical improvements like body balance after enrolling in a yoga program that involved physical activities such as walking.
Based on the previous literature, Portz et al. (2018) used the information to investigate whether physical fitness and exercise would be used as a clinical intervention for managing chronic stroke. After implementing the information, Portz et al. (2018) found that it is essential for health care professionals to incorporate self-management interventions such as physical fitness and exercise in managing chronic stroke among older adults. This will improve their quality of life, strength, and endurance by incorporating yoga practice. Furthermore, this kind of research will encourage more health care researchers to conduct translational research to reach phase 4 (T4), where yoga practice can be used as an evidence-based intervention for chronic stroke.
DQ Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
References
Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453
Schmid, A. A., Miller, K. K., Van Puymbroeck, M., & DeBaun-Sprague, E. (2014). Yoga leads to multiple physical improvements after stroke, a pilot study. Complementary Therapies in Medicine, 22(6), 994–1000. https://doiorg.lopes.idm.oclc.org10.1016/j.ctim.2014.09.005
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This is insightful Listra; stroke has been a major concern in the United States. However, over the last previous years, the incidences of stroke in the U.S. have declined. However, stroke incidence among older adults has always been higher than among younger adults, especially older women. Stroke is attributed to different factors, including overweight and unhealthy eating (Kamin et al., 2020). The translational research and the methodology that has been applied greatly provide insight into the incidences of stroke and the approaches that can be undertaken to enhance the significant reduction in the incidences of stroke in the entire United States of America. The type of translational research applied in the study identified is T4. The information acquired or obtained from the previous stages of research has been disseminated and implemented in the research process (Portz et al., 2018). Self-management interventions are critical in the management of cases of stroke. Some of the self-management procedures may include adherence to physical activities as well as measures that may reduce the cases of obesity.
References
Kamin Mukaz, D., Zakai, N. A., Cruz-Flores, S., McCullough, L. D., & Cushman, M. (2020). Identifying genetic and biological determinants of race-ethnic disparities in stroke in the United States. Stroke, 51(11), 3417-3424. https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.120.030425
Portz, J. D., Waddington, E., Atler, K. E., Van Puymbroeck, M., & Schmid, A. A. (2018). Self-management and yoga for older adults with chronic stroke: A mixed-methods study of physical fitness and physical activity. Clinical Gerontologist, 41(4), 374–381. https://doi-org.lopes.idm.oclc.org/10.1080/07317115.2016.1252453
Medicinal marijuana has been a growing interest and in fact, there are currently 36 states in the country that have laws making medical marijuana legal as of May 2021 (National Conference of State Legislatures [NCSL], 2021) The reason for that is because there have been numerous studies proving the health benefit from use for chronic pain, nausea, appetite stimulant and many other health concerns. The article I selected is a study looking at medical marijuana use in pediatric oncology patients.
This study consisted of 50 pediatric oncology patients who were prescribed medical marijuana for a variety of symptoms. They assessed patient and parent reported outcomes of pain, appetite, sleep, nausea and vomiting, mood, and other side effects. Side effects and safety was monitored and documented from the medical marijuana use. The results of this study showed that medical marijuana can potentially be useful in side effect management in the pediatric oncology population. Due to the low sample size, future studies are needed to truly assess the safety, efficacy and proper dosing of medical marijuana in the pediatric population (Ofir et al., 2019).
DQ Using the GCU Library (notably the GCU Library Nursing and Health Sciences Research Guide), find a database, journal, or other collection of resources that focuses on translational research
This study would be considered part of the T1 translational research looking at proof of concept by using a small sample size (Titler, 2018). It is important to always start out with a small sample size to ensure patient safety. Many would be concerned about the adverse effects of medicinal marijuana in the pediatric population, so it is important to show several translational research studies before implementing it into the general practice.
References
National Conference of State Legislatures. (2021, June 9). State Medical Marijuana Laws [Press release]. https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspx
Ofir, R., Bar-Sela, G., Weyl Ben-Arush, M., & Postovsky, S. (2019). Medical marijuana use for pediatric oncology patients: Single institution experience. Pediatric Hematology and Oncology, 36(5), 255–266. https://doi.org/10.1080/08880018.2019.1630537
Titler, M. G. (2018). Translation Research in Practice: An Introduction. Online Journal of Issues in Nursing, 23(2). https://doi.org/10.3912/OJIN.Vol23No02Man01
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This is insightful Kelli. Medicinal marijuana has been a growing interest, and in fact, there are currently 36 states in the country that have laws making medical marijuana legal as of May 2021 (National Conference of State Legislatures. Marijuana has a medicinal value and can be applied in different healthcare institutions to cure pain and enhance different treatment processes (National Conference of State Legislatures, 2021). There are different previous studies that have proved that marijuana has different medicinal values. The article selected provides the analysis of different cases when marijuana can be used in healthcare institutions. From the research conducted, the outcomes show that medical marijuana has been applied to manage different patients, especially during surgical processes (Paschall et al., 2017). The translational research that has been applied is T1. There is the application of proof of concepts in the article; also, there is the application of different strategies that have ensured effective research outcomes.
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